Kids* deserve protection from infection too.

*Two years of age and older.

You’re in the right place to learn about HyQvia^® [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] for kids and teens.

If you’re here, you’re likely a parent, caregiver, or pretty smart kid or teen seeking more information about PI and HyQvia. Maybe a doctor has mentioned the possibility of PI, there’s been a diagnosis, or you are new to HyQvia. However you found us, we’re so glad you’re here. You’ll find all kinds of info about PI, HyQvia, and what can be done to make your kiddo or teen feel more comfortable with infusions.

One of the main reasons parents come here is because of how infrequently their child may be able to infuse—up to every 28 days. That’s monthly infusions (every 3 or 4 weeks). Plus, infusing at home is a possibility too, with the protection from infection your child needs. Your child’s doctor will help you decide what’s best, but the possibility is there. Which is great because life is busy, and so are kids!

With HyQvia, your child may be able to infuse monthly
(every 3 or 4 weeks).

That’s once a month, as opposed to more frequent infusions. HyQvia is the only monthly subQ IG treatment. This flexible dosing schedule, prescribed by your child's doctor, allows your child to minimize the impact infusing can have on their daily routine. So, whether they just love to play, read, or they have a busy schedule, they may be able to do more of it because of fewer infusions per month.

How long is an average infusion?

HyQvia infusions were approximately an hour and a half in a study of 44 pediatric patients. (Coincidentally, the same amount of time as a movie.)

So how is this possible?

Hyaluronidase, or hy. Hy allows the body to absorb more IG, the medicine your child needs to help fight infections. Hy is infused first, followed by the IG.

With HyQvia, there are infusion options to fit every comfort level.

Your child has the option to infuse at home or in a center, and self-infusion (after appropriate training) or infusion with nurse assistance. You, your child, and the doctor can decide what’s right. It really depends on you and your child’s comfort level.

EFFECTIVENESS & SAFETY

How effective is HyQvia for children?

Let’s start with the study.

In pediatric patients, the study showed us there were:

• 0.04 acute serious bacterial infections (ASBIs) per patient-year

— One subject experienced two ASBIs of bacterial pneumonia

— This is equivalent to 40 ASBIs out of 1,000 patients over the course of the 12-month study period

— This is significantly less than the FDA standard for an IG medicine to be effective!

• 3.20 infections of any kind per patient-year, which is consistent with results in the adult clinical trial

0.04 ASBIs
per patient-year with HyQvia

~3 infections
per patient-year

Let’s back up for a sec in case you’re wondering what ASBIs are.

ASBIs are short-term but serious infections caused by bacteria that require immediate medical care. The FDA standard for efficacy—that is, if an immunoglobulin works—is less than 1 ASBI per year. In the clinical trial, people taking HyQvia experienced significantly less than that.

About the study

HyQvia was studied in a clinical trial of 44 pediatric patients with PI. The main goal of the study was to measure how many acute serious bacterial infections (ASBIs) they experienced over the course of 1 year.

Most children completed their infusions without interruption.

In a 12-month study of 2- to 16-year-olds:

• 99.8% of infusions were completed
• 94.1% were completed without interruption
• The safety results for pediatrics were similar
to those of adults

of infusions were completed

The most common adverse reactions observed in >5% of patients in the clinical trials were: local adverse reactions including pain, erythema, edema, and pruritus, and systemic adverse reactions including headache, antibody formation against Recombinant Human Hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.

ABOUT INFUSING

What can your child do during the infusion?

Great question. We know that it’s hard for kids to sit still. Period. No matter the age. The key to helping them through their infusion is to tap into their interests. Does your child love to craft? Stock up on crafting supplies and bust ’em out for their infusion. Does your child love to play video games? Let ’em play a little longer. Here are a few other ideas:

Video call with grandma,
grandpa, aunts, uncles,
cousins, friends

Read a book
or magazines

Play board
games

Color, draw,
sketch

Journal
(if they’re older)

Create something with
building bricks

What else helps?

Make a designated space for infusions that’s all theirs. It could have their favorite toys or stuffies, blankets, a pillow, pictures they love, etc. What we’re going for here is anything that will make them feel more comfortable. And it’s nice to have that to look forward to and help make the infusion experience more positive.

Build a fort!

If they’re still into imaginary playlands, make a special fort they can sit in during their infusion. (Safely, holding still of course.) They can pretend they’re on a pirate ship or in an igloo—their imagination is the limit.

Want to know what it’s like to infuse?

Learn the different ways to infuse from start to finish.

Watch the video

*Between infusions, based on administration every 3 or 4 weeks.

This guide can help you
talk with your doctor.

Our Doctor Discussion Guide can help you get your thoughts together, craft responses, and help you think of other questions you may have.

Get the guide

Want to learn more about paying for HyQvia?

Understandable. Here’s a link
to helpful co-pay info.

Learn more

Ask your doctor about
a free trial program.

HelloHYQVIA is a free trial program your child can be enrolled in (if eligible) that covers the entire cost of their first three infusions and supplies.

Go to resources

IMPORTANT SAFETY INFORMATION and serious warnings regarding blood clots

What is HYQVIA?

HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat primary immunodeficiency (PI) in people 2 years and older.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about HYQVIA?

HYQVIA can cause blood clots.
Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
Your HCP may perform blood tests regularly to check your IgG level.
Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.

Who should not take HYQVIA?

Do not take HYQVIA if you:

Are allergic to IgG, hyaluronidase, other blood products, or any ingredient in HYQVIA.

What should I avoid while taking HYQVIA?

HYQVIA can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your HCP that you take HYQVIA.

What should I tell my HCP before I start using or while using HYQVIA?

Tell your HCP if you:

Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
Are pregnant, trying to become pregnant or are breast feeding. It is not known whether HYQVIA can harm the unborn baby or breastfed infant.

What are the possible or reasonably likely side effects of HYQVIA?

HYQVIA can cause serious side effects. If any of the following problems occur after starting HYQVIA, stop the infusion immediately and contact your HCP or call emergency services:

Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
Fever over 100°F. This could be a sign of an infection.

After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. The following possible side effects may occur at the site of infusion and generally go away within a few hours, and are less likely after the first few infusions.

Mild or moderate pain
Redness
Swelling
Itching

The most common side effects of HYQVIA are:

Headache
Fatigue
Nausea
Fever
Vomiting

Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long-term effect. In theory, these antibodies could react with your body’s own hyaluronidase (PH20). PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side-effects.

These are not all the possible side effects. Talk to your HCP about any side effect that bothers you or that does not go away.

For additional safety information, click for Information For Patients and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.